Confirmed chronic Hepatitis B infection in persons with - HBV DNA greater than or equal to 1000 IU/mL AND - ALT levels greater than ULN OR - Evidence of fibrosis OR - Documented evidence of cirrhosis

For patients with chronic Hepatitis B infection who have a contraindication, intolerance or inadequate response to one or more of the following: lamivudine, entecavir, adefovir or telbivudine.

Patient is pregnant (2nd trimester or later) with HBV DNA greater than 1,000,000 IU/mL.

Patients with chronic Hepatitis B infection currently receiving treatment with tenofovir and requires treatment continuation.

Patients with chronic Hepatitis B infection who are scheduled to undergo chemotherapy or significant immunosuppressive treatment.

For HIV/AIDS.